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Fragile X mental retardation protein in plasticity and disease

✍ Scribed by Peter K. Todd; James S. Malter

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 139 KB
Volume: 70
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.10453

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✦ Synopsis

Abstract

Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome and the molecular mechanisms of learning and memory. We provide an overview of current concepts of how FMRP functions in the nervous system, with special emphasis on recent evidence that FMRP has a role in metabotropic glutamate receptor‐activated protein translation and synaptic plasticity. © 2002 Wiley‐Liss, Inc.

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