## Abstract Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insi
Fragile X mental retardation protein in learning-related synaptic plasticity
β Scribed by Valentina Mercaldo; Giannina Descalzi; Min Zhuo
- Publisher
- Korean Society for Molecular and Cellular Biology
- Year
- 2009
- Tongue
- English
- Weight
- 357 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1016-8478
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Fragile X mental retardation results from the absence of a selective RNA-binding protein, FMRP. Previous studies demonstrated that FMRP forms messenger ribonucleoprotein (mRNP) complexes to associate with translating polyribosomes, suggesting that FMRP is involved in regulating protein synthesis. We
## Abstract Fragile X syndrome (FXS) is the most common form of inherited mental retardation and is caused by the loss of function for Fragile X Mental Retardation Protein (FMRP), a selective RNAβbinding protein with a demonstrated role in the localized translation of target mRNAs at synapses. Seve