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Fragile X founder effects and new mutations in Finland

✍ Scribed by Zhong, Nan; Kajanoja, Eliisa; Smits, Bram; Pietrofesa, James; Curley, Dennis; Wang, Dauwen; Ju, Weina; Nolin, Sally; Dobkin, Carl; Ryynänen, Markku; Brown, W. Ted

Book ID
102645679
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
60 KB
Volume
64
Category
Article
ISSN
0148-7299

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✦ Synopsis

The apparent associations between fragile X mutations and nearby microsatellites may reflect both founder effects and microsatellite instability. To gain further insight into their relative contributions, we typed a sample of 56 unrelated control and 37 fragile X chromosomes from an eastern Finnish population for FMRl CGG repeat lengths, AGG interspersion patterns, DXS548, FRAXACl, FRAXE and a new polymorphic locus, A h -L . In the controls, the most common FMRl allele was 30 repeats with a range of 20 to 47 and a calculated heterozygosity of 88%.

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