Fragile sites and cancer genes on the short arm of chromosome 8
โ Scribed by Nicholas C Popescu
- Book ID
- 117783102
- Publisher
- The Lancet
- Year
- 2004
- Tongue
- English
- Weight
- 95 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1470-2045
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We have previously described the cytogenetic analysis of two patients with Greig cephalopolysyndactyly syndrome (GCPS) and various microdeletions on the short arm of Chromosome (Chr) 7. Using genes and anonymous DNA probes from 7p we analyzed the DNA of our patients for loss of heterozygosity, or we
We used I0 restriction fragment length polymorphism (RFLP) probes spanning the length of the short arm of chromosome 3 (3p) t o map deletion sites in human lung cancer. Two approaches were used. I) When a patient's tumor and normal tissue were available, loci with allelic heterozygosity in the norma