𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Localization of genes and anonymous DNA probes on the short arm of Chromosome 7

✍ Scribed by Klaus Wagner; Peter M. Kroisel; Walter Rosenkranz

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
318 KB
Volume
3
Category
Article
ISSN
0938-8990

No coin nor oath required. For personal study only.

✦ Synopsis

We have previously described the cytogenetic analysis of two patients with Greig cephalopolysyndactyly syndrome (GCPS) and various microdeletions on the short arm of Chromosome (Chr) 7. Using genes and anonymous DNA probes from 7p we analyzed the DNA of our patients for loss of heterozygosity, or we determined the copy number by semi-quantitative Southern hybridization. We have been able to show hemizygosity for the genes of INHBA, IGFBP1 and GLI3 in both patients and therefore can give the chromosomal assignment 7p12.3-p13. CRI-R944 and CRI-P137 map to the same region, whereas CRI-S207 can be assigned to 7p13-p14.2; TM102L, TS93, TS194, TM77 and TN177 showed no change and these probes map distal to 7p14.2.

πŸ“œ SIMILAR VOLUMES

Localization of HLA on the short arm of
Localization of HLA on the short arm of chromosome 6
✍ Martijn H. Breuning; Ella M. Berg-Loonen; Luigi F. Bernini; Jan B. Bijlsma; Erna πŸ“‚ Article πŸ“… 1977 πŸ› Springer 🌐 English βš– 562 KB

A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21;p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtai

A deletion panel of the long arm of the
A deletion panel of the long arm of the X chromosome: subregional localization of 22 DNA probes
✍ H. -M. Yang; T. Lund; E. Niebuhr; S. NΓΈrby; M. Schwartz; L. Shen πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 761 KB

Two males and two females with different but overlapping deletions on the proximal long arm of the X chromosomes have been investigated. Their karyotypes, which have been well characterized by high resolution banding techniques, are 46,Y,del(X)(pter----q21.1::q21.33----qter); 46,Y,del(X)(pter----q21