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Localization of HLA on the short arm of chromosome 6

✍ Scribed by Martijn H. Breuning; Ella M. Berg-Loonen; Luigi F. Bernini; Jan B. Bijlsma; Erna Loghem; P. Meera Khan; Lourens E. Nijenhuis

Publisher
Springer
Year
1977
Tongue
English
Weight
562 KB
Volume
37
Category
Article
ISSN
0340-6717

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✦ Synopsis

A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21;p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.

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