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Fragile Mitochondrial DNA: The Missing Link in the Apoptotic Neuronal Cell Death in Parkinson's Disease

✍ Scribed by Takayuki Ozawa; Mika Hayakawa; Kazumi Katsumata; Makoto Yoneda; Shin-ichiro Ikebe; Yoshikuni Mizuno

Book ID
115580366
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
82 KB
Volume
235
Category
Article
ISSN
0006-291X

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A number of factors have been implicated in the pathogenesis of cell death in Parkinson's disease (PD). These include oxidative stress, mitochondrial dysfunction, inflammation, excitotoxicity, and apoptosis. While the precise pathogenic mechanism leading to neurodegeneration in PD is not known, ther