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FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model

✍ Scribed by Osamu Yoshino; Yutaka Osuga; Kaori Koga; Yasushi Hirota; Tetsuya Hirata; Xie Ruimeng; Li Na; Tetsu Yano; Osamu Tsutsumi; Yuji Taketani


Book ID
113752510
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
266 KB
Volume
72
Category
Article
ISSN
0165-0378

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## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogen‐activated protein kinase (MAPK) and inhibits tumor necrosis factor Ξ± (TNFΞ±) and interleukin‐1Ξ² (IL‐1Ξ²) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagen‐induced arthritis (CIA).