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The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice

✍ Scribed by Hitoshi Ando; Seiichiro Kurita; Toshinari Takamura

Book ID: 116717246
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 482 KB
Volume: 74
Category: Article
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2003.09.045

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## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogen‐activated protein kinase (MAPK) and inhibits tumor necrosis factor α (TNFα) and interleukin‐1β (IL‐1β) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagen‐induced arthritis (CIA).