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FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing’s sarcoma cells

✍ Scribed by Liu Yang; Hsien-Ming Hu; Anna Zielinska-Kwiatkowska; Howard A. Chansky


Book ID
116300916
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
775 KB
Volume
402
Category
Article
ISSN
0006-291X

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## Abstract Ewing's Family Tumors (EFTs) most commonly harbor a specific t(11;22) translocation that generates the EWS/FLI1 fusion protein responsible for malignant transformation. Many potential downstream targets of EWS/FLI1 have been identified but a detailed mechanism by which the fusion protei