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Efficacy of siRNA Nanocapsules Targeted Against theEWS–Fli1Oncogene in Ewing Sarcoma

✍ Scribed by Nedjma Toub; Jean-Rémi Bertrand; Ali Tamaddon; Hind Elhamess; Hervé Hillaireau; Andrei Maksimenko; Jean Maccario; Claude Malvy; Elias Fattal; Patrick Couvreur

Book ID
106493077
Publisher
Springer US
Year
2006
Tongue
English
Weight
539 KB
Volume
23
Category
Article
ISSN
0724-8741

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## Abstract The __EWS__/__Fli‐1__ fusion gene, a product of the translocation t(11;22, q24;q12), is detected in 85% of Ewing sarcomas and primitive neuroectodermal tumors. It is thought to be a transcriptional activator that plays a significant role in tumorigenesis. In this study, we developed a n

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## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr