DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells
✍ Scribed by García-Aragoncillo, E; Carrillo, J; Lalli, E; Agra, N; Gómez-López, G; Pestaña, Á; Alonso, J
- Book ID
- 109970526
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 251 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr
## Abstract More than 90% of all Ewing's Sarcoma Family of Tumors (ESFT) exhibit specific chromosomal rearrangements between the __EWS__ gene on chromosome 22 and various members of the __ETS__ gene family of transcription factors. The gene fusion type and other secondary genetic alterations, mainl