A multicomponent molecular recognition process leads to a self‐assembled “quaternary” supramolecular complex formed from porphyrins and an “unusual” poly(A·A·U) triple helix. The formation of this superstructure is promoted by porphyrin aggregation and a number of recognition processes (Watson‐Crick
Formation of the Triple-Stranded Polynucleotide Helix, Poly(A· A· U)
✍ Scribed by Steven L. Broitman, Dwight D. Im and Jacques R. Fresco
- Book ID
- 123634497
- Publisher
- National Academy of Sciences
- Year
- 1987
- Tongue
- English
- Weight
- 955 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/29987
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## Abstract The slow kinetics of annealing processes in multistranded nucleic acids is spectrophotometrically investigated using poly(A)·2poly(U) as a model system. The absorbance changes at specific wavelengths show that double‐helical (A·U) base pairs appear as transient intermediates. The anneal
## Abstract The Zimm‐Bragg theory is extended to treat the melting of the triple helix poly (A + 2U) for a solution with a 1 : 2 mole ratio of poly A to poly U. Only the case for long chains is considered. For a given set of parameters the theory predicts the fraction of segments in the triple heli