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Formation of Ternary Complex of Factor VIIa, Tissue Factor, and Factor X on the Surface of Anionic Membrane

✍ Scribed by Ohkubo, Y. Zenmei; Tajkhorshid, Emad

Book ID
122155650
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
66 KB
Volume
102
Category
Article
ISSN
0006-3495

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✍ Daniel Kirchhofer; Yale Nemerson πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 637 KB

Tissue factor (TF), a transmembrane glycoprotein, functions as an essential activator of the serine protease factor Vlla. This enzymatic complex is considered to be the principal initiator of in vivo coagulation. Recent studies emphasize the role of the TF/Vlla complex in a number of pathophysiologi