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Tissue Factor/Factor VIIa Complex: Role of the Membrane Surface

✍ Scribed by James H. Morrissey; Emad Tajkhorshid; Stephen G. Sligar; Chad M. Rienstra

Book ID
116915018
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
141 KB
Volume
129
Category
Article
ISSN
0049-3848

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Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor Vlla complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the development of an amidine based linker which allowed th