Formation of oxazolines and thiazolines in peptides by the mitsunobu reaction
✍ Scribed by Nathalie Galéotti; Corine Montagne; Joël Poncet; Patrick Jouin
- Book ID
- 108380317
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 195 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The Mitsunobu reaction ± the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate ± is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid
Treatment of benzoic acid with triphenylphosphine and diisopropyl azodicarboxylate in THF or acetonitrile, results in the formation of benzoic anhydride. A significant solvent effect was observed for this reaction. Anhydride formation did not occur however with the more acidic pnitrobenzoic acid. Re
## Abstract Six members of a novel non‐__C__~2~‐symmetric ligand class incorporating an oxazoline and thiazoline unit have been prepared in a four‐step, high‐yielding and convergent synthesis, in which the key step is a microwave‐assisted palladium‐catalyzed aryl amination. The new ligands induced