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New Thiazoline–Oxazoline Ligands and Their Application in the Asymmetric Friedel–Crafts Reaction

✍ Scribed by Seán C. McKeon; Helge Müller-Bunz; Patrick J. Guiry

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
323 KB
Volume
2009
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Six members of a novel non‐C~2~‐symmetric ligand class incorporating an oxazoline and thiazoline unit have been prepared in a four‐step, high‐yielding and convergent synthesis, in which the key step is a microwave‐assisted palladium‐catalyzed aryl amination. The new ligands induced enantiomeric excesses of up to 76 % in the asymmetric Friedel–Crafts reaction.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

📜 SIMILAR VOLUMES

Synthesis of Thiazoline–Oxazoline Ligand
Synthesis of Thiazoline–Oxazoline Ligands and Their Application in Asymmetric Catalysis
✍ Seán C. McKeon; Helge Müller-Bunz; Patrick J. Guiry 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB 👁 1 views

## Abstract A series of novel ligands incorporating oxazoline and thiazoline units were synthesized in high yield by employing a convergent route, in which the key step is a microwave‐assisted palladium‐catalyzed aryl amination. The new ligands were tested in the zinc‐catalyzed Friedel–Crafts alkyl