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Formation of Optically Active Aromatic α-Amino Acids by Catalytic Enantioselective Addition of Imines to Aromatic Compounds

✍ Scribed by Steen Saaby; Xiangming Fang; Nicholas Gathergood; Karl Anker Jørgensen

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
84 KB
Volume
39
Category
Article
ISSN
0044-8249

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Formation of Optically Active Aromatic α
Formation of Optically Active Aromatic α-Amino Acids by Catalytic Enantioselective Addition of Imines to Aromatic Compounds
✍ Steen Saaby; Xiangming Fang; Nicholas Gathergood; Karl Anker Jørgensen 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

Optically active a-amino acids are vital to life as building blocks of peptides, proteins, and many other natural products. Amino acids are also applied extensively as food additives, pharmaceuticals, and agrochemicals. Furthermore, amino acids are widely used in organic synthesis as targets, and as

Catalytic Enantioselective Addition of N
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The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient con

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The development of CÀC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan