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Formation of covalent deoxyribonucleic acid benzo[a]pyrene 4,5-epoxide adduct in mouse and rat skin

✍ Scribed by Baer-Dubowska, W.; Frayssinet, Ch.; Alexandrov, K.


Book ID
123170986
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
364 KB
Volume
14
Category
Article
ISSN
0304-3835

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The formation and persistence of benzo(a
✍ Stephen W. Ashurst; Gerald M. Cohen πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 645 KB

## Abstract The extent of reaction of benzo(__a__)pyrene with DNA and the formation of benzo(__a__)pyrene‐deoxyribonucleoside adducts in the skins of male Wistar rats were investigated. Following topical application of benzo(__a__)pyrene (200 nmoles), binding reached a maximum of 0,74 pmoles/mg DNA