Fluoranthene and pyrene enhance benzo[a]pyrene—DNA adduct formation in vivo in mouse skin
✍ Scribed by Rice, Joseph E.; Hosted, Thomas J.; Lavoie, Edmond J.
- Book ID
- 121932166
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 503 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0304-3835
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## Abstract The hydrocarbon‐deoxyribonucleoside adducts formed in mouse skin DNA have been determined following topical application of an initiating dose of benzo(a)pyrene to Swiss mice, a strain shown to be susceptible to benzo(a)pyrene‐induced skin carcinogenesis. Several DNA‐bound products were
## Abstract The extent of reaction of benzo(__a__)pyrene with DNA and the formation of benzo(__a__)pyrene‐deoxyribonucleoside adducts in the skins of male Wistar rats were investigated. Following topical application of benzo(__a__)pyrene (200 nmoles), binding reached a maximum of 0,74 pmoles/mg DNA