Examination of Adduct Formation In Vivo in the Mouse between Benzo(a)pyrene and DNA of Skin and Hemoglobin of Red Blood Cells
✍ Scribed by Lee Shugart and John Kao
- Book ID
- 124276108
- Publisher
- Environmental Health Information Service
- Year
- 1985
- Tongue
- English
- Weight
- 202 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0091-6765
- DOI
- 10.2307/3430118
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## Abstract The extent of reaction of benzo(__a__)pyrene with DNA and the formation of benzo(__a__)pyrene‐deoxyribonucleoside adducts in the skins of male Wistar rats were investigated. Following topical application of benzo(__a__)pyrene (200 nmoles), binding reached a maximum of 0,74 pmoles/mg DNA
## Abstract The hydrocarbon‐deoxyribonucleoside adducts formed in mouse skin DNA have been determined following topical application of an initiating dose of benzo(a)pyrene to Swiss mice, a strain shown to be susceptible to benzo(a)pyrene‐induced skin carcinogenesis. Several DNA‐bound products were