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Formation and stability of helical poly (Nϵ, Nϵ, Nϵ-trimethyl-L-lysine) in sodium perchlorate solution

✍ Scribed by Jake Bello

Publisher
Wiley (John Wiley & Sons)
Year
1988
Tongue
English
Weight
738 KB
Volume
27
Category
Article
ISSN
0006-3525

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✦ Synopsis

Poly(trimethy1-L-lysine), [Lys(Mq)],, is converted from random coil to a-helix at about 1/30 of the NaC10, concentration required by poly(L-lysine), (Lys),. NaClO, generates turbidity in [Lys(Me),], at concentrations above that required for helix formation, and decreases turbidity above 1M NaC10,. The turbidity runs parallel to enhanced, and then decreased, fluorescence of a dansyl label. Helix formation per se does not induce enhanced fluorescence. Increasing NaC10, concentration increases T, linearly with log[NaClO,] for both (Lys), and [Lys(Mq], until the denaturing effect of high NaC10, sets in. Increasing NaClO, also increases the breadth of the transition. Heating helical [Lys(Mq)], or (Lys), does not produce a CD spectrum resembling that of "random-coil" (Lys),, except for [Lys(Mq)], at relatively low NaC10, concentration.

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