**Application of the α‐Alkynone Cyclization: Total Synthesis of (±)‐Albene** A synthesis of the racemic form of the natural tricyclic hydrocarbon albene **(1)** from the __Diels‐Alder__ adduct **2** of tiglyl chloride and cyclopentadiene is described (24% yield). The key step **5→6** involves a the
✦ LIBER ✦
Formale Totalsynthese von (±)-Isocomen durch Anwendung der α-Alkinon-Cyclisierung
✍ Scribed by Giuseppe G. G. Manzardo; Martin Karpf; André S. Dreiding
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- German
- Weight
- 764 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0018-019X
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**Application of the α‐Alkynone Cyclization: Synthesis of __rac__‐Modhephene** __rac__‐Modhephene **1**, the first sesquiterpene with a propellane C‐skeleton and its epimer __rac__‐__epi__‐modhephene **27**, were synthesized starting from bicyclo[3.3.0]oct‐1(5)‐en‐2‐one (**2**). The key step in the