A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.
Formal total synthesis of xestoquinone via furan ring transfer reaction strategy
β Scribed by Ken Kanematsu; Seizo Soejima; Guilin Wang
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 203 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A formal total synthesis of the marine natural product xestoquinone ( 5) based upon FRT reaction strategy is accomplished by preparation of the pentacyclic furan 6, an advanced key intermediate in Harada's previous total synthesis of this target.
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