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Formal Synthesis of Anisomycin.

โœ Scribed by Meng-Yang Chang; Shui-Tein Chen; Nein-Chen Chang


Publisher
John Wiley and Sons
Year
2003
Weight
80 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of N-Benzylhomo-(-)-anisomycin. -The title compound (VII), an analogue of the antibiotic anisomycin, is prepared starting from allylic amide (I) by ozonolysis followed by opening of the epoxide with Grignard reagent. The resulting alcohol (III) is reduced to (IV) with Et 3 SiH. Several de