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ChemInform Abstract: Synthesis of N-Benzylhomo-(-)-anisomycin.

✍ Scribed by G. KIM; H. W. HONG; S. H. LEE

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199830279

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✦ Synopsis

Synthesis of N-Benzylhomo-(-)-anisomycin.

-The title compound (VII), an analogue of the antibiotic anisomycin, is prepared starting from allylic amide (I) by ozonolysis followed by opening of the epoxide with Grignard reagent. The resulting alcohol (III) is reduced to (IV) with Et 3 SiH. Several deprotection steps give (VII). -(KIM, G.;

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