ChemInform Abstract: Formal Total Synthesis of Enantiopure (-)-Anisomycin, Antibiotic from Streptomyces.

✍ Scribed by Philippe Delair; Elisabeth Brot; Alice Kanazawa; Andrew E. Greene

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199929232

✦ Synopsis

Formal Total Synthesis of Enantiopure (-)-Anisomycin, Antibiotic from Streptomyces.

-Starting from easily available, enantiopure, dual purpose inductor (I) highly enantioselective formal total synthesis of (-)-anisomycin (X) is achieved in approximately 8% overall yield. It is based on an effective asymmetric [2 + 2]-cycloaddition of enol ether (V) with in situ generated dichloroketone and synthesis of enantiopure hydroxy pyrrolidine (IX) in 27% overall yield from (I). -(DELAIR,