Formal [4 + 1]- and [5 + 1]-Annulation by an S N 2–Conjugate Addition Sequence: Stereoselective Synthesis of Highly Substituted Carbocycles
✍ Scribed by Tong, Benny Meng Kiat; Chen, Hui; Chong, Sin Yee; Heng, Yi Li; Chiba, Shunsuke
- Book ID
- 126980901
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 717 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A novel route towards the polyhydroxylated pyrrolizidine alkaloid (+)‐alexine has been developed. A key step in this synthesis is a highly stereoselective [3+2] annulation reaction of __N__‐Ts‐α‐amino aldehyde **7 a** (Ts=tosyl) and 1,3‐bis(silyl)propene **8 a** for the construction of
## Abstract An efficient protocol for the highly regio‐ and stereoselective synthesis of 4‐(3′‐hydroxy‐2′‐iodoalk‐1′(__Z__)‐enyl)furan‐2(5__H__)‐one derivatives __via__ selective iodohydroxylation of non‐heteroatom‐substituted allenes, i.e., 4‐allenyl‐2(5__H__)furanones, has been developed. The reg