✦ LIBER ✦
Highly Regio- and Stereoselective Iodohydroxylation of Non- Heteroatom-Substituted Allenes: An Efficient Synthesis of 4-[3′-Hydroxy-2′-iodoalk-1′(Z)-enyl]-2(5H)-furanone Derivatives
✍ Scribed by Zhenhua Gu; Youqian Deng; Wei Shu; Shengming Ma
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 91 KB
- Volume
- 349
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
An efficient protocol for the highly regio‐ and stereoselective synthesis of 4‐(3′‐hydroxy‐2′‐iodoalk‐1′(Z)‐enyl)furan‐2(5__H__)‐one derivatives via selective iodohydroxylation of non‐heteroatom‐substituted allenes, i.e., 4‐allenyl‐2(5__H__)furanones, has been developed. The regio‐ and stereoselectivity of this reaction may be controlled by the electronic and steric effects of the furanone ring.