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Forensic toxicologic analysis of methamphetamine and amphetamine in body materials by gas chromatography/mass spectrometry

โœ Scribed by Hara, Kenji ;Nagata, Takeaki ;Kimura, Kojiro

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
594 KB
Volume
96
Category
Article
ISSN
1437-1596

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โœฆ Synopsis

Qualitative and quantitative analysis of methamphetamine and amphetamine in biologic materials was carried out by gas chromatography/ mass spectrometry. A deuterium-labeled methamphetamine was employed as an internal standard with a detection limit of 50 pg and absolute stability and reproducibility. Blood was found to be the best material for estimation of the toxicity of the stimulant drug. It can be replaced by muscle which contains methamphetamine concentrations dose to those of blood. The authors' classification of the toxic blood levels of methamphetamine from therapeutic to fatal doses was confirmed by additional data obtained from new case studies.

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