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Simultaneous quantitative analysis of methamphetamine and 4-hydroxymethamphetamine in body fluids by gas chromatography/mass spectrometry

✍ Scribed by Hara, K. ;Kageura, M. ;Hieda, Y. ;Kashimura, S.

Publisher: Springer-Verlag
Year: 1988
Tongue: English
Weight: 328 KB
Volume: 100
Category: Article
ISSN: 1437-1596
DOI: 10.1007/bf00201158

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✦ Synopsis

Pentodeuterated 4-hydroxymethamphetamine(HMAMP-d5),l-(4-hydroxyphenyl)-2-(methyl-d3-amino)-propane-l,2-d2 of high quality was prepared and proved to be a most useful internal standard for quantitative analyses of 4-hydroxymethamphetamine (HMAMP), a main metabolite of methamphetamine(MAMP). Highly reliable results were obtained by gas chromatography/mass spectrometry. Simultaneously we determined also MAMP, amphetamine(AMP), 4-hydroxyamphetamine(HAMP), and HMAMP in body fluids, using two internal standards, HMAMP-d5 for HMAMP and HAMP and pentodeuterated methamphetamine, 1-phenyl-2-(methyl-d3-amino)-propane-l,2-d2, for MAMP and AMP.

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