Folic acid-modified methotrexate-conjugated PEGylated poly(ε-caprolactone) nanoparticles for targeted delivery
✍ Scribed by Ousanee Issarachot,Jiraphong Suksiriworapong…
- Book ID
- 121479828
- Publisher
- Springer Netherlands
- Year
- 2014
- Tongue
- English
- Weight
- 660 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1388-0764
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To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed b
## Abstract The layer‐by‐layer (LbL) assembly technique was applied for the surface modification of biodegradable poly(lactide‐__co__‐glycolide) nanoparticles (NPs), employing poly(acrylic acid) (PAA), and polyethylenimine (PEI) as building blocks. Amino terminated poly(ethylene glycol) (PEG) and f