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Folate levels and methylation of CDKI proteins

✍ Scribed by Gabriele Buda; Valentina Maggini; Sara Galimberti; Roberto Barale; Anna Maria Rossi; Mario Petrini


Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
93 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis


The purpose of this study was to investigate WT1 expression levels in childhood acute leukemia. Bone marrow from 14 children with acute leukemia at diagnosis and from 7 children with solid tumors without bone marrow involvement (control group) was studied. Five of the 14 patients (35.7%), expressed high levels of WT1. Four of the five WT1 positive patients with additional adverse prognostic factors, have succumbed to their disease. The results of this study are in accordance with the fact that high levels of WT1 expression have been reported in patients with an unfavorable outcome.


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