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Folate-Decorated Succinylchitosan Nanoparticles Conjugated with Doxorubicin for Targeted Drug Delivery

✍ Scribed by Sumanta Kumar Sahu; Swatilekha Maiti; Tapas Kumar Maiti; Sudip K. Ghosh; Panchanan Pramanik

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
778 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Amphiphilic biodegradable succinylchitosan nanoparticles modified with folic acid are described that act as an emulsifier to form nanoparticles. Their molecular structures and physicochemical as well as self‐assembly properties are characterized by means of FT‐IR, ^1^H NMR, FESEM, DLS, and TEM. The nanoparticles are 60–80 nm in size and are not toxic in vitro. They are immobilized with the cytostatic drug doxorubicin. Specific transport of doxorubicin by the nanoparticles into the folate‐receptor‐overexpressing cancer cells and its biological activity as well as in vitro release are demonstrated. It is shown that under acidic condition more drug is released. The nanoparticles can thus not only specifically deliver doxorubicin to its target, but also release the drug depending on the pH.
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