Anticancer Drug Delivery: Doxorubicin-Conjugated Immuno-Nanoparticles for Intracellular Anticancer Drug Delivery (Adv. Funct. Mater. 11/2009)

✍ Scribed by Meng Shi; Karyn Ho; Armand Keating; Molly S. Shoichet

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 442 KB
• Volume: 19
• Category: Article
• ISSN: 1616-301X
• DOI: 10.1002/adfm.200990046

✦ Synopsis

Self-assembled polymeric nanoparticles of the amphiphilic copolymer poly(TMCC-co-LA)-g-PEG-furan can couple both anti-HER2 antibodies and chemotherapeutic doxorubicin (DOX) on their surfaces, report Molly Shoichet and co-workers. This novel strategy selectively delivers DOX to the cell nucleus of HER2overexpressing breast cancer cells while maintaining the pharmaceutical toxicity of DOX, paving the way to targeted drug delivery in breast cancer treatment.