Thermosensitive Micelles Based on Folate-Conjugated Poly(N-vinylcaprolactam)-block-Poly(ethylene glycol) for Tumor-Targeted Drug Delivery

✍ Scribed by Mani Prabaharan; Jamison J. Grailer; Douglas A. Steeber; Shaoqin Gong

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 427 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200800366

✦ Synopsis

Abstract

Thermosensitive PNVCL‐b‐PEG block copolymer coupled with folic acid was prepared as an anti‐cancer drug carrier. This polymer self‐assembled into stable micelles in aqueous solutions at above 33 °C. At 37 °C, the release profile of PNVCL‐b‐PEG‐FA micelles showed a slower and more controlled release of the entrapped 5‐FU than that at 25 °C. The blank and 5‐FU‐loaded PNVCL‐b‐PEG‐FA micelles did not induce remarkable cytotoxicity against the EA.hy 926 human endothelial cell line; however, 5‐FU‐loaded PNVCL‐b‐PEG‐FA micelles showed a cytotoxicity effect against 4T1 mouse mammary carcinoma cells due to the availability of loaded anti‐cancer drugs delivered to the inside of the cancer cells by the folate‐receptor‐mediated endocytosis process.

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