Folate and Methylenetetrahydrofolate Reductase Polymorphisms: New Nutritional and Genetic Risk Factors for Pancreatic Cancer?
โ Scribed by Kim, Young-In
- Book ID
- 122375569
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 242 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1542-3565
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Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677CยจT, is the first genetic risk factor for NTDs in man identified at the molec
The present chapter aims to illustrate some key concepts of genetic association studies, with an emphasis on meta -analysis as a powerful study design to summarize quantitatively the results of the scientifi c literature. Additionally, a systematic review of the published meta -analyses of the effec