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Methylenetetrahydrofolate Reductase Polymorphisms, Folate, and Cancer Risk: A Paradigm of Gene-Nutrient Interactions in Carcinogenesis

✍ Scribed by Young-In Kim


Book ID
111435373
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
526 KB
Volume
58
Category
Article
ISSN
0029-6643

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Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec