Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer
β Scribed by E. Vairaktaris; C. Yapijakis; P. Kessler; A. Vylliotis; J. Ries; J. Wiltfang; S. Vassiliou; S. Derka; F. W. Neukam
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 187 KB
- Volume
- 132
- Category
- Article
- ISSN
- 1432-1335
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Persons with a thermolabile form of the enzyme 5,lO methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid. Thermolability of the enzyme has recently been shown to be caused by a common mutation (677C
Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play a role in DNA methylation, synthesis, and repair. The genetic mutations in MTHFR and TYMS genes may have influences on their respective enzyme activities. Data on the association studies of the MTHFR and TY