Focusing in on P53 in hepatocellular carcinoma

✍ Scribed by David Carbone

• Book ID: 102239278
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 366 KB
• Volume: 14
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840140430

✦ Synopsis

Human hepatocellular carcinomas (HCC) from patients in Qidong, an area of high incidence in China, in which both hepatitis B virus and afiatoxin B, are risk factors, were analysed for mutations in p53, a putative tumour-suppressor gene. Eight of the 16 HCC had a point mutation at the third base position of codon 249. The G-T transversion in seven HCC DNA samples and the G-rC transversion in the other HCC are consistent with mutations caused by afiatoxin B, in mutagenesis experiments. No mutations were found in exons 5 , 6 , 8