Fmoc Solid Phase Synthesis of Polyamides Containing Pyrrole and Imidazole Amino Acids
โ Scribed by Wurtz, Nicholas R.; Turner, James M.; Baird, Eldon E.; Dervan, Peter B.
- Book ID
- 120256510
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 53 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1523-7060
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๐ SIMILAR VOLUMES
The synthesis of the Nsc-protected amino acid, Nsc-Py-OH 1a, and its oligomerization are described.
The incorpmation of O-phosphotyrosine into synthetic peptides using Pmoc-Tyr(PO Me of the modef & )-OH in the Fmoc-polyamide procedure is described uith the preparation yr-tridecapeptide sequence H-Arg-Leu-IZe-GZu-Asp-Asn-GZu-flyr-Thr-Ala-Arg-GZn-GZy-OH.
The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method und