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Fluorous electrophilic scavengers for solution-phase parallel synthesis

✍ Scribed by Wei Zhang; Christine Hiu-Tung Chen; Tadamichi Nagashima

Book ID
104253106
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
341 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and b-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mixture by solid-phase extractions (SPE) over FluoroFlashβ„’ cartridges to give products with good purity. The SPE cartridges can be reused.

πŸ“œ SIMILAR VOLUMES

Fluorous-tethered quenching reagents for
Fluorous-tethered quenching reagents for solution phase parallel synthesis
✍ Craig W. Lindsley; Zhijian Zhao; William H. Leister πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 124 KB

Commercially available fluorous-tethered reagents are employed to quench excess reactants and remove known impurities from crude reaction mixtures generated via solution phase parallel synthesis. Fluorous quenching reagents are expediently removed via FluoroFlashβ„’ SPE columns to afford products in h