Various types of fluorine-containing a.B-unsaturated acids and their esters were synthesized from 2-trilfuoromethylacrylic acid as a sole starting material.
Fluorine-containing organozinc reagents - VI. The preparation of α-Trifluoromethyl-α,β-unsaturated carboxylic acid esters
✍ Scribed by Thomas Allmendinger; Robert W. Lang
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 148 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The consecutive reaction of phosphonates **1** with __n__‐butyllithium, trifluoroacetic anhydride, and organozinc compounds gives trifluoromethylated α,β‐unsaturated esters with an active methylene moiety and predominant __Z__‐selectivity in 54–78% (3 steps) yields. © 2004 Wiley Periodi
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