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The reaction of organozinc reagents with trifluoroacylated phosphonates: Synthesis of trifluoromethylated α, β-unsaturated esters with an active methylene moiety

✍ Scribed by Yanchang Shen; Jiahong Ni


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
85 KB
Volume
15
Category
Article
ISSN
1042-7163

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✦ Synopsis


Abstract

The consecutive reaction of phosphonates 1 with n‐butyllithium, trifluoroacetic anhydride, and organozinc compounds gives trifluoromethylated α,β‐unsaturated esters with an active methylene moiety and predominant Z‐selectivity in 54–78% (3 steps) yields. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:289–292, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20018


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