Fluorescence in situ hybridization for detecting TP16MTS1/CDK41 gene deletions in squamous cell carcinoma of the head and neck
β Scribed by Ali Namazie; Sassan Alavi; Neema Aghamohammadi; Mazda Aghamohammadi; Thomas C Calcaterra; Marilene B Wang; Eri S Srivatsan
- Book ID
- 114135463
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 345 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0165-4608
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Genomic heterogeneity has been observed in several solid tumor types. To investigate this phenomenon in head and neck squamous cell carcinoma (HNSCC), we analyzed macroscopically distinct tissue samples of 12 resected tumors by a combination of fluorescence in situ hybridization (FISH) and DNA flow
## Abstract ## BACKGROUND Cyclin D1 (__CCND1__) and __p16__ alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The
## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci