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Fluorescence in situ hybridization in fine-needle aspiration for detecting cyclin D1 numerical aberrations and P16 deletions in oral squamous cell carcinomas

โœ Scribed by N. Uzawa; R. Miyamoto; K. Myo; I. Sonoda; Y. Yuki; T. Amagasa

Book ID
117610443
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
280 KB
Volume
34
Category
Article
ISSN
0901-5027

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## Abstract ## BACKGROUND Cyclin D1 (__CCND1__) and __p16__ alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The

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## Abstract ## BACKGROUND Amplification of chromosome 11q13 is a frequent event in carcinogenesis of the head and neck squamous cell carcinomas including oral carcinoma. ## METHODS Fluorescence in situ hybridization (FISH), using a BAC clone specific for the cyclin D1 gene (__CCND1__), was perfo