Fluctuation in structure of inclusion complexes of cyclodextrins with fluorescent probes
β Scribed by Asao Nakamura; Kunihiko Saitoh; Fujio Toda
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 506 KB
- Volume
- 187
- Category
- Article
- ISSN
- 0009-2614
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## Abstract Cyclodextrins (CDs) are visualized by fluorimetric detection based on inclusion complexation with fluorescence probes in microcolumn liquid chromatography. Visualization of CDs is attributed to the fact that the fluorescence intensity of 2β__p__βtoluidinylnaphthaleneβ6βsulfonate or othe
## Abstract An inclusion complex of fenbufen with Ξ²βcyclodextrin (Ξ²βCD) in aqueous solution was characterized by ^1^HβNMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (__M__^β1^) was calculated. The geometry of the inclusion complex was established
The crystal structure of the inclusion complex of Ξ²-cyclodextrin (Ξ²-CD) synthesized with felbinac (4-biphenylacetic acid) was determined by single crystal X-ray diffraction at 150 K. The complex contains two Ξ²-CDs, two felbinac molecules, twenty-two water molecules in the asymmetric unit, and could