Crystal Structure of β-Cyclodextrin-Felbinac Inclusion Complex

✍ Scribed by Enju Wang; Guangying Chen; Hong Liu

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 109 KB
• Volume: 27
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200990353

✦ Synopsis

The crystal structure of the inclusion complex of β-cyclodextrin (β-CD) synthesized with felbinac (4-biphenylacetic acid) was determined by single crystal X-ray diffraction at 150 K. The complex contains two β-CDs, two felbinac molecules, twenty-two water molecules in the asymmetric unit, and could be formulated as

In the crystal lattice, the two β-CD moieties form a head-to-head dimer jointed through hydrogen bonds, and the felbinacs that interact by face-to-face π-π stacking are included in the β-CD dimer cavity with their carboxyl groups protruding out from cavity opening. In crystals the dimer units of β-CD are stacked in an intermediate type (IM) that consists of closely packed β-CD dimer layers.