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FK506 ameliorates cell death features in Huntington’s disease striatal cell models

✍ Scribed by Tatiana R. Rosenstock; Olga Martins de Brito; Vitoria Lombardi; Susana Louros; Marcio Ribeiro; Sandra Almeida; Ildete Luisa Ferreira; Catarina R. Oliveira; A. Cristina Rego

Book ID
116765691
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
832 KB
Volume
59
Category
Article
ISSN
0197-0186

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## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom