## Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat region in exon 1 of the HD gene. This mutation results in the presence of an abnormally long polyglutamine tract in the encoded protein, huntingtin (htt). A major question in this fiel
✦ LIBER ✦
Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells
✍ Scribed by Márcio Ribeiro; Tatiana R. Rosenstock; Teresa Cunha-Oliveira; Ildete L. Ferreira; Catarina R. Oliveira; A. Cristina Rego
- Book ID
- 118447300
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 909 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0891-5849
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## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom